00857nas a2200145 4500008004100000245012100041210006900162260000800231300001600239490000700255520026700262100002600529700002800555856012800583 2015 eng d00aChiral pool approach for the synthesis of functionalized amino acids: synthesis of antiepileptic drug (R)-lacosamide0 aChiral pool approach for the synthesis of functionalized amino a cAUG a5802–58030 v563 a

An efficient total synthesis of (R)-lacosamide 1 has been achieved from N-Boc-N,O-isopropylidene-l-serinol 2 which could easily be obtained from natural l-serine. Our synthesis of 1 starting from 2 using chiral pool strategy resulted in 54% overall yield.

1 aAratikatla, Eswar, K.1 aBhattacharya, Asish, K. uhttps://library.ncl.res.in/content/chiral-pool-approach-synthesis-functionalized-amino-acids-synthesis-antiepileptic-drug-r