01568nas a2200205   4500008004100000245014000041210006900181260000800250300001600258490000700274520081900281100001801100700001801118700002101136700001901157700002401176700002001200700001701220856012501237       2011                        eng d00aPhotoactive RuII-polypyridyl complexes that display sequence selectivity and high-affinity binding to duplex DNA through groove binding0 aPhotoactive RuIIpolypyridyl complexes that display sequence sele  cFEB  a2089–20980 v173 a<p>The duplex-DNA binding properties of a nonintercalating polypyridyl ruthenium(II) complex that incorporates a linear extended ligand with a catechol moiety has been probed with a variety of photo- and biophysical techniques. These studies reveal that the complex groove binds to DNA sequences biphasically, and displays binding constants equivalent to those of high-affinity metallointercalators. The complex also displays preferential binding to AT-rich sequences. Changes in the structure of the coordinated catechol ligand and the incorporation of intercalating ancillary ligands into the complex were found to modulate both the optical-binding response and binding parameters of the system, which indicates that the catechol moiety plays a crucial role in the observed enhancement to binding affinities.</p>1 aGhosh, Amrita1 aDas, Priyadip1 aGill, Martin, R.1 aKar, Prasenjit1 aWalkar, Michael, G.1 aThomas, Jim, A.1 aDas, Amitava  uhttps://library.ncl.res.in/content/photoactive-ruii-polypyridyl-complexes-display-sequence-selectivity-and-high-affinity