01179nas a2200181 4500008004100000245016900041210006900210260000800279300001600287490000700303520037700310653008200687100001600769700002200785700002300807700002400830856014300854 2007 eng d00aNovel reaction of the “huisgen zwitterion” with chalcones and dienones: an efficient strategy for the synthesis of pyrazoline and pyrazolopyridazine derivatives0 aNovel reaction of the huisgen zwitterion with chalcones and dien cMAR a2070–20730 v463 a

Two unexpected transformations: The reaction of the Huisgen zwitterion derived from triphenylphosphane and diisopropyl azodicarboxylate (DIAD) with chalcones affords functionalized pyrazolines. In contrast, the reaction with dienones affords pyrazolopyridazines, presumably by Diels–Alder reaction of the initially formed pyrazoline with excess DIAD (see scheme).

10achalcones; nitrogen heterocycles; pyrazolines; synthetic methods; zwitterions1 aNair, Vijay1 aBiju, Akkattu, T.1 aMathew, Smitha, C.1 aEringathodi, Suresh uhttps://library.ncl.res.in/content/novel-reaction-%E2%80%9Chuisgen-zwitterion%E2%80%9D-chalcones-and-dienones-efficient-strategy-synthesis