01618nas a2200169 4500008004100000245012400041210006900165260000800234300001600242490000700258520096300265100002201228700002401250700002401274700002601298856012401324 2015 eng d00aUnimolecular antiparallel G-quadruplex folding topology of 2'-5'-isoTBA sequences remains unaltered by loop composition0 aUnimolecular antiparallel Gquadruplex folding topology of 25isoT cOCT a11696-117030 v133 a

A 2'-5'-linked isoTBA 15 mer sequence with (232) loop composition formed stable antiparallel quadruplex structures similar to the SELEX derived 15 mer TBA sequence with (232) loop composition. A parallel versus antiparallel topology of 3'-5'-G-quadruplexes is largely dictated by the loop length, and it is known that the truncated loops favour parallel quadruplexes. In contrast to TBA, systematic reduction of the loop length in isoTBA from (232) to (222), (131) or even (111) did not alter the antiparallel topology of the resulting 14 mer, 13 mer and 11 mer G-rich modified isoTBA-like sequences.

 

1 aAher, Manisha, N.1 aErande, Namrata, D.1 aFernandes, Moneesha1 aKumar, Vaijayanti, A. uhttps://library.ncl.res.in/content/unimolecular-antiparallel-g-quadruplex-folding-topology-2-5-isotba-sequences-remains