01234nas a2200181 4500008004100000245013800041210007000179260000800249300001400257490000700271520052900278100002300807700002300830700001700853700002400870700002200894856013600916 2015 eng d00aN-Heterocyclic carbene-catalyzed diastereoselective synthesis of β-lactone-fused cyclopentanes using homoenolate annulation reaction0 aNHeterocyclic carbenecatalyzed diastereoselective synthesis of β cMAY a9559-95620 v513 a

NHC-catalyzed annulation of enals with 2-enoylpyridines or 2-enoylpyridine N-oxides leading to the diastereoselective synthesis of β-lactone-fused cyclopentanes is reported. The reaction proceeds via the generation of homoenolate equivalent intermediates and tolerates a broad range of functional groups.

1 aMukherjee, Subrata1 aMondal, Santigopal1 aPatra, Atanu1 aGonnade, Rajesh, G.1 aBiju, Akkattu, T. uhttps://library.ncl.res.in/content/n-heterocyclic-carbene-catalyzed-diastereoselective-synthesis-%CE%B2-lactone-fused-cyclopentanes