01411nas a2200181   4500008004100000245014900041210006900190260000800259300001400267490000600281520070200287100001700989700001701006700003301023700002401056700002201080856012701102       2015                        eng d00aDiastereoselective synthesis of cyclopentanone-fused spirooxindoles by N-heterocyclic carbene-catalyzed homoenolate annulation with isatilidenes0 aDiastereoselective synthesis of cyclopentanonefused spirooxindol  cSEP  a1584-15880 v23 a<p>N-Heterocyclic carbene (NHC)-catalyzed formal [3 + 2] annulation of α,β-unsaturated aldehydes with N-substituted isatilidenes resulting in the diastereoselective synthesis of cyclopentanone-fused spirooxindoles is demonstrated. Mechanistically, the reaction proceeds via the generation of homoenolate equivalent intermediates from NHC and enals, which on interception with isatilidenes afford spiroheterocyclic compounds bearing an all-carbon quaternary spiro-center in moderate to good yields and generally with high diastereoselectivity. Moreover, the functionalization of the spirooxindoles as well as the initial studies on the enantioselective version of this reaction are presented.</p>1 aPatra, Atanu1 aBhunia, Anup1 aYetra, Santhivardhana, Reddy1 aGonnade, Rajesh, G.1 aBiju, Akkattu, T.  uhttps://library.ncl.res.in/content/diastereoselective-synthesis-cyclopentanone-fused-spirooxindoles-n-heterocyclic-carbene