01595nas a2200181   4500008004100000022001400041245008700055210006900142260011000211300001400321490000700335520085400342100002301196700002301219700002801242700002701270856011601297       2016                        eng d  a1463-926200aLigand-free Pd catalyzed cross-coupling reactions in an aqueous hydrotropic medium0 aLigandfree Pd catalyzed crosscoupling reactions in an aqueous hy  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcNOV  a1898-19110 v183 a<p>A simple, efficient and ligand-free protocol for the Suzuki-Miyaura reaction and base-free Heck-Matsuda reactions under mild reaction conditions have been developed over palladium supported on activated carbon (Pd/C) in an aqueous hydrotropic solution. The catalyst Pd/C was fully characterized by TG-DTA, SEM, EDS, XRD, XPS, BET and ICP-AES analyses. This green methodology represents a cost-effective and operationally convenient method for the synthesis of a variety of biaryls, prochiral ketones, and acrylates under the conditions that are tolerant for a broad range of functional groups with good to excellent yields. The developed Pd/C-aqueous hydrotrope combined catalytic system is well suited for the 3R approach (reducible, robust, and recyclable) for different cross-coupling reactions without an appreciable loss of its activity.</p>1 aJadhav, Sanjay, N.1 aKumbhar, Arjun, S.1 aRode, Chadrashekhar, V.1 aSalunkhe, Rajashri, S.  uhttps://library.ncl.res.in/content/ligand-free-pd-catalyzed-cross-coupling-reactions-aqueous-hydrotropic-medium