01443nas a2200169   4500008004100000022001400041245016400055210006900219260011000288300001600398490000600414520067300420100002501093700002801118700002101146856010601167       2016                        eng d  a2046-206900aUnified approach to pyrrole-embedded aza-heterocyclic scaffolds based on the RCM/isomerization/cyclization cascade catalyzed by a Ru/B-H binary catalyst system0 aUnified approach to pyrroleembedded azaheterocyclic scaffolds ba  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcMAR  a34428-344330 v63 a<p>An easy and straightforward preparation of pyrrole-embedded aza-heterocyclic scaffolds employing a Ru/B-H binary catalyst system has been developed. The strategy generates a diverse array of privileged scaffolds from 2-aminophenyl group appended pyrroles that can be prepared by a two-step process from corresponding aminoaryl-substituted pyrroles. The technique of incorporating 2-aminoaromatic groups in the heterocycles and their subsequent ring-closing-metathesis (RCM) isomerization followed by subsequent Pictet-Spengler type reaction should also be applicable to other heterocycles for generating a library of multi-ring compounds in an efficient manner.</p>1 aInamdar, Suleman, M.1 aChakrabarty, Indradweep1 aPatil, Nitin, T.  uhttps://library.ncl.res.in/content/unified-approach-pyrrole-embedded-aza-heterocyclic-scaffolds-based