01714nas a2200205   4500008004100000022001400041245010400055210006900159260011000228300001400338490000700352520086400359100003001223700002401253700002601277700003101303700002301334700002601357856012501383       2016                        eng d  a1144-054600aFacile synthesis of new N-sulfonamidyl-4-thiazolidinone derivatives and their biological evaluation0 aFacile synthesis of new Nsulfonamidyl4thiazolidinone derivatives  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcFEB  a3047-30580 v403 a<p>The one-pot three-component syntheses of new N-sulfonamide-thiazolidin-4-one derivatives were carried out in excellent yield using [HDBU][HSO4] as an ionic liquid under solvent-free conditions. The newly synthesized compounds were screened against fungal strains and a number of compounds were seen to display excellent antifungal activity. In addition, the synthesized compounds were screened for their scavenging activity of the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical and showed very good antioxidant activity. Finally, theoretical predictions derived from molecular docking studies against the potential target sterol 14 alpha-demethylase (CYP51) helped establish a link between the observed biological activity and the binding affinity, thereby providing insights into the specific bonding and non-bonding interactions governing the activity.</p>1 aSubhedar, Dnyaneshwar, D.1 aShaikh, Mubarak, H.1 aKhan, Firoz, A. Kalam1 aSangshetti, Jaiprakash, N.1 aKhedkar, Vijay, M.1 aShingate, Bapurao, B.  uhttps://library.ncl.res.in/content/facile-synthesis-new-n-sulfonamidyl-4-thiazolidinone-derivatives-and-their-biological