01330nas a2200205   4500008004100000022001400041245012700055210006900182260011000251300001400361490000700375520049600382100001500878700001800893700001900911700002300930700002500953700001700978856012900995       2016                        eng d  a1359-734500aSpecific receptor for hydrazine: mapping the in situ release of hydrazine in live cells and in an in vitro enzymatic assay0 aSpecific receptor for hydrazine mapping the in situ release of h  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcMAR  a6166-61690 v523 a<p>We report a new chemodosimetric reagent capable of detecting hydrazine in the presence of several other competing amine derivatives and ionic analytes of biological relevance. This reagent has been utilized for real time monitoring of in situ N2H4 release during the metabolism of a crucial tuberculosis drug, isoniazid, in live HepG2 cells. The fluorescence response of the reagent based on its specific reaction with N2H4 is used for developing an in vitro assay for aminoacylase-1.</p>1 aAli, Firoj1 aAnila, H., A.1 aTaye, Nandaraj1 aMogare, Devraj, G.1 aChattopadhyay, Samit1 aDas, Amitava  uhttps://library.ncl.res.in/content/specific-receptor-hydrazine-mapping-situ-release-hydrazine-live-cells-and-vitro-enzymatic