01437nas a2200229   4500008004100000022001400041245017700055210006900232260007500301300001400376490000700390520052700397653001400924653002300938653002000961653001200981653001800993100002501011700002601036700002201062856012301084       2016                        eng d  a0936-521400aFormal enantioselective synthesis of (-)-epiquinamide by proline-catalyzed one-pot sequential -amination/propargylation of aldehyde and asymmetric dihydroxylation of olefin0 aFormal enantioselective synthesis of epiquinamide by prolinecata  aRUDIGERSTR 14, D-70469 STUTTGART, GERMANYbGEORG THIEME VERLAG KGcJUL  a1699-17020 v273 a<p>Two independent routes to the formal synthesis of (-)-epiquinamide, have been described: the first route utilizes an l-proline-catalyzed one-pot sequential -amination/propargylation of aldehyde, while the second one employs asymmetric dihydroxylation as the key reaction to install the stereochemistry. While the first synthesis was accomplished in nine steps with 24.4% overall yield and dr 9:1, the second strategy resulted in the synthesis in eight steps with 36.4% overall yield and with perfect enantiocontrol.</p>10aAmination10adiastereoselective10aDihydroxylation10aProline10aquinolizidine1 aAhuja, Brij, Bhushan1 aEmmanuvel, Lourdusamy1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/formal-enantioselective-synthesis-epiquinamide-proline-catalyzed-one-pot-sequential