01328nas a2200181   4500008004100000022001400041245015200055210006900207260007100276300001400347490000700361520055800368100002400926700002100950700002500971700002400996856012601020       2016                        eng d  a1523-706000aRadical beckmann rearrangement and its application in the formal total synthesis of antimalarial natural product isocryptolepine via C-H activation0 aRadical beckmann rearrangement and its application in the formal  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcJUL  a3450-34530 v183 a<p>The Beckmann rearrangement of ketoximes, mediated by ammonium persulfate-dimethyl sulfoxide as a reagent, has been achieved under neutral conditions. Based on the radical trapping and O-18-labeling experiments, the transformation follows a mechanism involving a radical pathway. The scope and generality of the developed protocol has been demonstrated by 19 examples. The developed protocol and Pd-catalyzed intramolecular double C-H activation were used as key steps in the formal total synthesis of antimalarial natural product isocryptolepine.</p>1 aMahajan, Pankaj, S.1 aHumne, Vivek, T.1 aTanpure, Subhash, D.1 aMhaske, Santosh, B.  uhttps://library.ncl.res.in/content/radical-beckmann-rearrangement-and-its-application-formal-total-synthesis-antimalarial