01913nas a2200253   4500008004100000022001400041245013700055210006900192260007300261300001000334490000800344520099500352653001201347653002301359653001601382653000601398653001701404653002301421653001601444100002201460700001801482700002901500856013001529       2005                        eng d  a1381-116900aSelective synthesis of N,N-dimethyl aniline derivatives using dimethyl carbonate as a methylating agent and onium salt as a catalyst0 aSelective synthesis of NNdimethyl aniline derivatives using dime  aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcFEB  a49-560 v2263 a<p>N-Alkylation of anilines by dimethyl carbonate (DMC) catalyzed by onium salts has been demonstrated. The work presented here shows that a simple catalytic system consisting of onium salts in the presence of a small amount of water is extremely effective in enhancing the DMC mediated N-alkylation of anilines to dialkylated products. The effect of reaction conditions on the synthesis of N,N-dimethyl aniline (NNDMA) from aniline and DMC has been investigated. Under the optimized conditions highest yield of NNDMA obtained was 99.8%, which is the best reported for liquid phase N-alkylation of aniline using DMC. The role of water in enhancing the yield of NNDMA is explained and a reaction-networking scheme is constructed, which summarizes the chemistry behind liquid phase N-alkylation of anilines by DMC. The catalyst has been shown to recycle up to five times and at the end of fifth recycle almost 98% of NNDMA yields were obtained. (C) 2004 Elsevier B.V. All rights reserved.</p>10aAniline10aDimethyl carbonate10amethylation10aN10aN-alkylation10aN-dimethyl aniline10aonium salts1 aShivarkar, A., B.1 aGupte, S., P.1 aChaudhari, Raghunath, V.  uhttps://library.ncl.res.in/content/selective-synthesis-nn-dimethyl-aniline-derivatives-using-dimethyl-carbonate-methylating-0