01124nas a2200193   4500008004100000022001400041245018200055210006900237260007100306300001400377490000700391520029000398100002400688700002500712700002300737700002300760700002300783856012400806       2005                        eng d  a0022-326300aDiastereoselective amidoalkylation of (3S,7aR)-6-benzyl-7-hydroxy-3-phenyltetra-hydro-5H-imidazo[1,5-c][1, 3]thiazol-5-one : a short and highly efficient synthesis of (+)-biotin0 aDiastereoselective amidoalkylation of 3S7aR6benzyl7hydroxy3pheny  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcMAR  a1901-19030 v703 a<p>A short and highly efficient synthesis of W-biotin in 10 steps with 20% overall yield has been achieved from L-cysteine involving amidoalkylation of hydroxy imidazothiazolone 4 via an acyliminium ion intermediate to furnish C-7-substituted imidazothiazolones 5b as the key step.</p>1 aChavan, Subhash, P.1 aChittiboyina, A., G.1 aRavindranathan, T.1 aKamat, Subhash, K.1 aKalkote, Uttam, R.  uhttps://library.ncl.res.in/content/diastereoselective-amidoalkylation-3s7ar-6-benzyl-7-hydroxy-3-phenyltetra-hydro-5h-1