01246nas a2200181   4500008004100000022001400041245015300055210006900208260010600277300001400383490000700397520046000404100001400864700002100878700002100899700001900920856012500939       2005                        eng d  a0957-416600aSimple and practical approach to enantiomerically pure (S)-3-hydroxy-gamma-butyrolactone: synthesis of (R)-4-cyano-3-hydroxybutyric acid ethyl ester0 aSimple and practical approach to enantiomerically pure S3hydroxy  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcAUG  a2717-27210 v163 a<p>The oxidation of alpha- or beta-(1,4) linked disaccharides or oligosaccharides with cumene hydroperoxide in the presence of a base gave (S)-3,4-dihydroxybutyic acid, which was cyclized under acidic conditions to furnish (S)-3-hydroxy-gamma-butyrolactone. This was subsequently converted into (R)-cyano-3-hydroxybutyric acid ethyl ester, an intermediate for statin based drugs and other related compounds. (c) 2005 Elsevier Ltd. All rights reserved.</p>1 aKumar, P.1 aDeshmukh, A., N.1 aUpadhyay, R., K.1 aGurjar, M., K.  uhttps://library.ncl.res.in/content/simple-and-practical-approach-enantiomerically-pure-s-3-hydroxy-gamma-butyrolactone-0