01787nas a2200313   4500008004100000022001400041245009100055210006900146260006900215300001000284490000700294520075800301653000601059653003201065653003601097653001401133653002401147653002301171653001201194653001801206653001201224653002301236100002501259700001301284700002301297700001201320700002601332856011501358       2005                        eng d  a1369-703X00aNovel enzymatic route for kinetic resolution of (+/-)1,4-benzodioxan-2-carboxylic acid0 aNovel enzymatic route for kinetic resolution of 14benzodioxan2ca  aPO BOX 564, 1001 LAUSANNE, SWITZERLANDbELSEVIER SCIENCE SAcDEC  a66-710 v273 aEthyl 1,4-benzodioxan-2-carboxylate is used as an intermediate compound for the production of drug doxazosin mesylate. The title compound was kinetically resolved to get S-enantiomer of ethyl 1,4-benzodioxan 2-carboxylate in a simple lipase catalyzed transesterificafion reaction. Ethyl acetate was used as reaction medium as well as acyl donor. The influence of the enzyme source and time of reaction on the enantio selectivity of product were studied. Lipase from Candida antartica-B (Novozyme A/S) catalyzed transesterification reaction with good enantio selectivity towards S-enantiomer. The high enantiomeric ratio, E= 160, provided S-2 an acceptable chemical yield (50%) and enaritiomeric excess (>95%). (c) 2005 Elsevier B.V. All rights reserved.10a110a4-benzodioxan-2-carboxylate10a4-benzodioxan-2-carboxylic acid10adoxazosin10aenantio selectivity10aenantiomeric ratio10aethyl 110aethyl acetate10aLipases10atransesterfication1 aKasture, Sangita, M.1 aVarma, R1 aKalkote, Uttam, R.1 aNene, S1 aKulkarni, Bhaskar, D.  uhttps://library.ncl.res.in/content/novel-enzymatic-route-kinetic-resolution-14-benzodioxan-2-carboxylic-acid-0