02231nas a2200157   4500008004100000022001400041245009100055210006900146260010100215300001400316490000700330520157400337100002301911700002901934856011001963       2005                        eng d  a0888-588500aNew route for the synthesis of propylene glycols via hydroformylation of vinyl acetate0 aNew route for the synthesis of propylene glycols via hydroformyl  aPortoroz-Portorose, SloveniabAmer Chemical Soc, 1155 16th ST, NW, Washington, DC 20036 USAcDEC  a9601-96080 v443 a<p>Hydroformylation of vinyl acetate (VAM) has been studied as a key step in the alternative route for the synthesis of 1,2-propanediol (1,2-PDO) and 1,3-propanedol (1,3-PDO) using homogeneous rhodium (Rh) and cobalt (Co) complex catalysts. The feasibility of the VAM hydroformylation route has been demonstrated, and a detailed study has been reported on the key hydroformylation step using homogeneous Rh and Co catalysts. The roles of the catalyst precursors, ligands, and solvents in the activity and regioselectivity of the aldehyde products, i.e., 2-acetoxy propanal (2-ACPAL) and 3-acetoxy propanal (3-ACPAL), and the effect of reaction conditions have been investigated. With Rh-phosphine catalysts, 2-ACPAL is obtained with a selectivity of &gt; 90%, while with cobalt carbonyl catalyst, 2-ACPAL and 3-ACPAL are formed with comparable selectivities (similar to 50% each) thus substantially improving the selectivity of the linear aldehyde, a precursor for 1,3-PDO. In halogenated solvents with cobalt carbonyl catalyst, the selectivity to 3-ACPAL was found to increase still further (58%). A possible mechanism to explain the variation in regioselectivity for the Rh anal Co catalysts has been discussed. In the presence of pyridine as a ligand in the Co-catalyzed hydroformylation of VAM, the rate of reaction was found to be enhanced 4-fold. The hydrogenation of acetoxypropanal isomers using Raney-Ni catalyst followed by hydrolysis using Amberlite IR-120 resin catalyst gave quantitative conversion to the mixture of 1,2- and 1,3-PDOs (&gt; 90% yield).</p>1 aBorole, Yogesh, L.1 aChaudhari, Raghunath, V.  uhttps://library.ncl.res.in/content/new-route-synthesis-propylene-glycols-hydroformylation-vinyl-acetate-0