01734nas a2200241   4500008004100000022001400041245018600055210006900241260010600310300001400416490000700430520077100437653001601208653001301224653001301237653001101250653001201261653001801273100002401291700002301315700002501338856012901363       2006                        eng d  a0040-402000aCyclitol based metal complexing agents. preference for the extraction of lithium by myo-inositol based crown-4-ethers depends on the relative orientation of crown ether oxygen atoms0 aCyclitol based metal complexing agents preference for the extrac  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcMAY  a4360-43630 v623 a<p>myo-Inositol derived crown-4-ethers in which two of the oxygen atoms in the crown ether moiety have different relative orientations were prepared. Metal picrate binding studies revealed that the crown ether having 1,3-diaxial orientation shows the highest selectivity for binding to lithium although the crown ether having 1,2-diequatorial orientation exhibited the highest binding constant for lithium picrate. These results suggest that relative binding affinity of metal ions to crown ethers can be tuned by varying the relative orientation of crown ether oxygen atoms. The relevance of these results to the previously observed regioselectivity during the O-substitution of myo-inositol orthoesters is discussed. (c) 2606 Elsevier Ltd. All rights reserved.</p>10acrown ether10aCyclitol10aInositol10aligand10alithium10ametal complex1 aDixit, Shailesh, S.1 aShashidhar, M., S.1 aDevaraj, Subramanian  uhttps://library.ncl.res.in/content/cyclitol-based-metal-complexing-agents-preference-extraction-lithium-myo-inositol-based-0