00898nas a2200157 4500008004100000022001400041245007100055210006600126260007100192300001400263490000700277520032400284100001400608700001800622856010000640 2006 eng d a0022-326300aEnantio- and diastereocontrolled total synthesis of (+)-boronolide0 aEnantio and diastereocontrolled total synthesis of boronolide a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcMAY a3935-39410 v713 a

An efficient stereoselective total synthesis of (+)-boronolide from valeraldehyde is described. The key steps include a Sharpless asymmetric hydroxylation, a chelation-controlled vinyl Grignard reaction followed by a Sharpless asymmetric epoxidation, hydrolytic kinetic resolution, and a ring-closing metathesis.

1 aKumar, P.1 aNaidu, S., V. uhttps://library.ncl.res.in/content/enantio-and-diastereocontrolled-total-synthesis-boronolide-0