01475nas a2200181   4500008004100000022001400041245017300055210006900228260007100297300001400368490000700382520068800389100001901077700002601096700002601122700001501148856013001163       2006                        eng d  a0022-326300aConvergent approach toward the synthesis of the stereoisomers of C-6 homologues of 1-deoxynojirimycin and their analogues: evaluation as specific glycosidase inhibitors0 aConvergent approach toward the synthesis of the stereoisomers of  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcOCT  a8481-84880 v713 a<p>A new and stereoselective strategy is developed to synthesize an appropriate template 9 to obtain C-6 homologues of 1-deoxyazasugars such as 1-deoxy-D-galactohomonojirimycin ( 5), 1-deoxy-4-hydroxymethyl-D-glucohomonojirimycin (6), and their enantiomers. The template 9 is also used to obtain neutral nonbasic pseudo-glyconolactam (8), C-4 amino, and methyl analogues of 1-deoxy- homonojirimycin as new analogues of 1- deoxyhomoazasugars. Compound 5 is found to be a potent and specific inhibitor to alpha-galactosidase (K-i = 1.7 mu M). Similarly compounds 6 (K-i = 28 mu M), ent-5 (K-i = 129 mu M), and ent-6 K-i = 12 mu M) exhibited specific inhibition of beta-glucosidase.</p>1 aPandey, Ganesh1 aDumbre, Shrinivas, G.1 aKhan, Mohammad, Islam1 aShabab, M.  uhttps://library.ncl.res.in/content/convergent-approach-toward-synthesis-stereoisomers-c-6-homologues-1-deoxynojirimycin-and-0