02289nas a2200253   4500008004100000022001400041245015800055210006900213260006800282300001400350490000800364520129800372653003101670653002301701653002701724653001701751653001601768100002201784700002501806700002501831700002801856700002701884856012401911       2007                        eng d  a0021-899500aPreparation and evaluation of cellulose acetate butyrate and poly(ethylene oxide) blend microspheres for gastroretentive floating delivery of repaglinide0 aPreparation and evaluation of cellulose acetate butyrate and pol  a111 RIVER ST, HOBOKEN, NJ 07030 USAbJOHN WILEY & SONS INCcSEP  a2764-27710 v1053 a<p>In this study, hollow microspheres of cellulose acetate butyrate (CAB) and poly(ethylene oxide) (PEO) were prepared by emulsion-solvent evaporation method. Repaglinide was successfully encapsulated into floating microspheres. Various formulations were prepared by varying the ratio of CAB and PEO, drug loading and concentration of poly(vinyl alcohol) (PVA) solution. Encapsulation of the drug up to 95% was achieved. The microspheres tend to float over the simulated gastric media for more than 10 h. The micromeritic properties of microspheres reveal the excellent flow and good packing properties. The % buoyancy of microspheres was found to be up to 87. SEM showed that microspheres have many pores on their surfaces. Particle size ranges from 159 to 601 mu m. DSC and X-RD revealed the amorphous dispersion in the polymer matrix. In vitro release experiments were performed in simulated gastric fluid. In vitro release studies indicated the dependence of release rate on the extent of drug loading and the amount of PEO in the microspheres; slow release was extended up to 12 h. The release data were fitted to an empirical equation to compute the diffusional exponent (n), which indicated that the release mechanism followed the non-Fickian trend. (C) 2007 Wiley Periodicals, Inc.</p>10acellulose acetate butyrate10aControlled release10afloating drug delivery10amicrospheres10arepaglinide1 aRokhade, Ajit, P.1 aPatil, Sangamesh, A.1 aBelhekar, Anagha, A.1 aHalligudi, Shivaraj, B.1 aAminabhavi, Tejraj, M.  uhttps://library.ncl.res.in/content/preparation-and-evaluation-cellulose-acetate-butyrate-and-polyethylene-oxide-blend-0