02010nas a2200265   4500008004100000022001400041245010100055210006900156260007300225300001400298490000600312520107800318653002301396653001701419653001401436653001401450653002401464653001501488100002301503700002801526700001701554700001901571700002301590856013101613       2007                        eng d  a1566-736700aSynthesis of tinidazole by condensation-oxidation sequence using MoO3/SiO2 bifunctional catalyst0 aSynthesis of tinidazole by condensationoxidation sequence using   aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcOCT  a1550-15550 v83 a<p>Antimicrobial drug, tinidazole has been synthesized by condensation of 2-methyl,5-nitro-imidazole and 2-ethyl-thio-ethanol over MoO3/SiO2 catalyst to obtain 1-(2-ethyl-thio-ethanol)-2-methyl-5-nitro-imidazole which is further oxidized using hydrogen peroxide using the same MoO3/SiO2 catalyst to obtain tinidazole. MoO3/SiO2 catalyst (20%), synthesized by sol-gel process showed the highest acid strength and was successfully demonstrated to catalyze both condensation and oxidation in the synthesis of tinidazole. Due to the bifunctional activity of the catalyst, the use of acetic acid for condensation step and tungstic acid or ammonium molybdate for oxidation step in the conventional synthesis of tinidazole could be eliminated, thus making it an environmentally benign process. The catalysts could be recycled five times without any appreciable loss in the conversion and selectivity showing the potential for. the use of MoO3/SiO2 as bifunctional catalyst for the production of this industrially important compound. (C) 2007 Elsevier B.V. All rights reserved.</p>10aantimicrobial drug10acondensation10aMoO3/SiO210aOxidation10asolid acid catalyst10atinidazole1 aChandorkar, J., G.1 aUmbarkar, Shubhangi, B.1 aRode, C., V.1 aKotwal, V., B.1 aDongare, Mohan, K.  uhttps://library.ncl.res.in/content/synthesis-tinidazole-condensation-oxidation-sequence-using-moo3sio2-bifunctional-catalyst-0