01383nas a2200217   4500008004100000022001400041245015700055210006900212260010600281300001600387490000700403520047100410653002300881653001800904653001400922653002300936100002500959700002300984700002601007856013201033       2007                        eng d  a0040-402000aEfficient synthesis of 2,4-disubstituted thiazoles using ionic liquid under ambient conditions: a practical approach towards the synthesis of Fanetizole0 aEfficient synthesis of 24disubstituted thiazoles using ionic liq  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcNOV  a11066-110690 v633 a<p>A highly efficient and rapid synthesis of 2-amino-4-arylthiazoles and 2-methyl-4-arylthiazole from alpha-bromoketone and thiourea/thioamide is described using room temperature ionic liquid at ambient conditions. The method is simple, rapid and practical, generating thiazole derivatives in excellent isolated yields. This protocol is utilized for a commercially feasible synthesis of an anti-inflammatory agent, Fanetizole. (c) 2007 Published by Elsevier Ltd.</p>10aalpha-bromo ketone10aionic liquids10athiazoles10athiourea/thioamide1 aPotewar, Taterao, M.1 aIngale, Sachin, A.1 aSrinivasan, Kumar, V.  uhttps://library.ncl.res.in/content/efficient-synthesis-24-disubstituted-thiazoles-using-ionic-liquid-under-ambient-conditions-0