01625nas a2200217   4500008004100000022001400041245010200055210006900157260008600226300001400312490000700326520081000333653001701143653001601160653002101176653002301197100002101220700001801241700002601259856012201285       2008                        eng d  a0039-791100aNovel process for the synthesis of class I antiarrhythmic agent (+/-)-cibenzoline and its analogs0 aNovel process for the synthesis of class I antiarrhythmic agent   a325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USAbTAYLOR & FRANCIS INCcAUG  a2967-29820 v383 a<p>Synthesis of (+/-)-cibenzoline and its analogs has been achieved by a simple sequence of reactions. The diaryl cyanoolefin intermediate 3 could be prepared by Knoevenagel condensation of benzophenone with ethylcyanoacetate to form the tetra-substituted olefin intermediate 2 followed by Krapcho deethoxycarbonylation or from beta-hydroxynitrile intermediate 2' followed by the elimination of hydroxyl group respectively. The 2,2-diphenylcyclopropanecarbonitrile 4 was synthesized from intermediate 3 by cyclopropanation, which was converted to (+/-)-2-(2,2-diphenylcyclopropyl)-2-imidazoline 5 by reaction with ethylenediamine in the presence of a catalytic amount of sulfur. Moreover, the obtained 2-imidazolines were smoothly oxidized to the corresponding imidazoles 6 in good to moderate yields.</p>10aBenzophenone10acibenzoline10acyclopropanation10adiaryl cyanoolefin1 aGholap, Atul, R.1 aPaul, Vincent1 aSrinivasan, Kumar, V.  uhttps://library.ncl.res.in/content/novel-process-synthesis-class-i-antiarrhythmic-agent-cibenzoline-and-its-analogs-0