01368nas a2200181   4500008004100000022001400041245011500055210006900170260010600239300001400345490000700359520059900366100002600965700002300991700002601014700001901040856012701059       2008                        eng d  a0040-402000aFacile air-oxidation of N-homopiperonyl-5,6-dimethoxyhomophthalimide: simple and efficient access to nuevamine0 aFacile airoxidation of Nhomopiperonyl56dimethoxyhomophthalimide   aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcFEB  a1786-17910 v643 a<p>A facile six-step synthesis of naturally occurring (+/-)-nuevamine with 55% overall yield has been described, starting from methyl 2-(6-formyl-2,3-dimethoxyphenyl)acetate via the quantitative benzylic air-oxidation of the corresponding N-homopiperonyl-5,6-dimethoxy-homophthalimide to N-homopiperonyl-5,6-dimethoxyisoquinoline-1,3,4-trione as the key reaction, followed by base catalyzed regioselective alcoholysis of the trione with ring contraction, acid catalyzed dehydrative ring closure of the formed lactamol and decarboxylation pathway. (C) 2007 Elsevier Ltd. All rights reserved.</p>1 aWakchaure, Prasad, B.1 aEaswar, Srinivasan1 aPuranik, Vedavati, G.1 aArgade, N., P.  uhttps://library.ncl.res.in/content/facile-air-oxidation-n-homopiperonyl-56-dimethoxyhomophthalimide-simple-and-efficient-0