01502nas a2200181   4500008004100000022001400041245014500055210006900200260010600269300001400375490000700389520070700396100002301103700002401126700002401150700002801174856011801202       2008                        eng d  a0040-403900aPre-organization-mediated macrocylization: efficient synthesis and structural investigations of BINOL-m-phenylenediamine-derived macrocycles0 aPreorganizationmediated macrocylization efficient synthesis and   aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcMAR  a2139-21420 v493 a<p>This letter describes a serendipitous discovery of an efficient synthetic route to BINOL-m-phenylenediamine-derived macrocycles. These macrocycles are quickly accessible in an one-pot procedure by the direct condensation of (R) and (S) BINOL bis-acids with suitably substituted m-phenylenediamine analogs. Structural investigations by single crystal X-ray crystallography and solution-state NMR studies provided convincing evidence of their intramolecular hydrogen bonding arrangement and rigid structural architecture. The striking feature of these macrocycles is their ready accessibility in optically pure form coupled with their ease of synthesis. (C) 2008 Elsevier Ltd. All rights reserved.</p>1 aSrinivas, Deekonda1 aGonnade, Rajesh, G.1 aRajamohanan, P., R.1 aSanjayan, Gangadhar, J.  uhttps://library.ncl.res.in/content/pre-organization-mediated-macrocylization-efficient-synthesis-and-structural-0