01609nas a2200229   4500008004100000022001400041245010700055210006900162260011000231300001400341490000600355520070600361100002501067700002101092700002201113700001901135700002601154700002301180700002501203700002401228856012701252       2008                        eng d  a1477-052000aSynthesis and biological evaluation of bile acid dimers linked with 1,2,3-triazole and bis-beta-lactam0 aSynthesis and biological evaluation of bile acid dimers linked w  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcOCT  a3823-38300 v63 a<p>We report herein the synthesis and biological evaluation of bile acid dimers 11-18 linked through 1,2,3-triazole and bis-beta-lactam. The dimers 11-18 were synthesized using 1,3-dipolar cycloaddition reaction of diazido bis-beta-lactams 3, 4 and terminal alkynes 7-10 derived from cholic acid/deoxycholic acid in the presence of Cu(I) catalyst (click chemistry). These novel molecules were evaluated in vitro for their antifungal and antibacterial activity. Most of the compounds exhibited significant antifungal as well as antibacterial activity against all the tested fungal and bacterial strains. Moreover, their in vitro cytotoxicities towards HEK-293 and MCF-7 cells were also established.</p>1 aVatmurge, Namdev, S.1 aHazra, Braja, G.1 aPore, Vandana, S.1 aShirazi, Fazal1 aDeshpande, Mukund, V.1 aKadreppa, Sreenath1 aChattopadhyay, Samit1 aGonnade, Rajesh, G.  uhttps://library.ncl.res.in/content/synthesis-and-biological-evaluation-bile-acid-dimers-linked-123-triazole-and-bis-beta-0