01185nas a2200169   4500008004100000022001400041245010800055210006900163260010600232300001400338490000700352520045800359100001800817700003000835700002200865856012800887       2008                        eng d  a0040-403900aShort enantioselective synthesis of (-)-bestatin via L-proline-catalyzed alpha-amination of an aldehyde0 aShort enantioselective synthesis of bestatin via Lprolinecatalyz  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcNOV  a6791-67930 v493 a<p>A short and high yielding enantioselective synthesis of (-)-bestatin, a naturally occurring aminopeptidase inhibitor, is described Via L-proline-catalyzed asymmetric alpha-amination of 3-phenylpropionaldehyde as the key reaction. The methodology also involves a Pd-catalyzed intramolecular cyclization of an allylic acetate giving a trans-oxazoline in a highly diastereoselective manner (dr &gt; 14:1). (C) 2008 Elsevier Ltd. All rights reserved.</p>1 aGeorge, Shyla1 aSuryavanshi, Gurunath, S.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/short-enantioselective-synthesis-bestatin-l-proline-catalyzed-alpha-amination-aldehyde-0