01062nas a2200169   4500008004100000022001400041245005800055210005400113260010600167300001000273490000700283520044100290100002600731700002500757700002200782856008800804       2009                        eng d  a0957-416600aConcise enantioselective synthesis of (+)-febrifugine0 aConcise enantioselective synthesis of febrifugine  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJAN  a84-880 v203 a<p>A short enantioselective synthesis of (+)-febrifugine, a potent antimalarial alkaloid, has been described based on the regioselective asymmetric dihydroxylation of a 1,4-dienic ester as the key step. The strategy also involves chemoselective [3,3]-sigmatropic rearrangement of 1,5-hexadiene-3-ol and intramolecular lactamization of azidolactone for the construction of piperidine core. (C) 2008 Elsevier Ltd. All rights reserved.</p>1 aEmmanuvel, Lourdusamy1 aKamble, Dayanand, A.1 aSudalai, Arumugam  uhttps://library.ncl.res.in/content/concise-enantioselective-synthesis-febrifugine-0