01506nas a2200229   4500008004100000022001400041245016600055210006900221260010600290300001400396490000700410520050800417653003000925653005100955653001301006653004601019653001501065100002001080700002901100700001901129856012801148       2009                        eng d  a0040-402000aGeneral approach to medium-sized ring ethers via hydrolytic and oxidative kinetic resolutions: stereoselective syntheses of (-)-cis-lauthisan and (+)-isolaurepan0 aGeneral approach to mediumsized ring ethers via hydrolytic and o  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcMAR  a2226-22310 v653 a<p>A short and enantioselective approach to medium ring ethers and its application to the syntheses of (-)-cis-lauthisan and (+)-isolaurepan are described. The synthetic strategy features Jacobson's Hydrolytic Kinetic Resolution (HKR), oxidative resolution of secondary alcohol, and highly diastereoselective Et(3)SiH/TMSOTf-promoted reductive cyclization of a hydroxy ketone to give exclusively the different medium-sized cis-disubstituted cyclic ethers. (C) 2009 Elsevier Ltd. All rights reserved.</p>10acis-Reductive cyclization10aJacobson's Hydrolytic Kinetic Resolution (HKR)10aOxepanes10aOxidative resolution of secondary alcohol10aRing ether1 aTripathi, Divya1 aPandey, Satyendra, Kumar1 aKumar, Pradeep  uhttps://library.ncl.res.in/content/general-approach-medium-sized-ring-ethers-hydrolytic-and-oxidative-kinetic-resolutions-0