02674nas a2200253   4500008004100000022001400041245011100055210006900166260005700235300001200292490000700304520174800311653001802059653004402077653003102121653001402152653002102166100001802187700002402205700002502229700001902254700002302273856012402296       2009                        eng d  a1530-993200aModulation and optimization of drug release from uncoated low density porous carrier based delivery system0 aModulation and optimization of drug release from uncoated low de  a233 SPRING ST, NEW YORK, NY 10013 USAbSPRINGERcJUN  a547-5580 v103 a<p>The purpose of this research work was to explore an application of uncoated porous drug carrier prepared by single-step drug adsorption for a delivery system based on integration of floating and pulsatile principles intended for chronotherapy. This objective was achieved by utilizing 3(2) factorial design, solvent volume (X (1)) and drug amount (X (2)) as selected variables, for drug adsorption using solvents, methanol, and dichloromethane (DCM), of varying polarity. Nitrogen adsorption (N(2)), scanning electron microscopy of cross-sections, and atomic force microscopy were done to study adsorption patterns and their effect on release pattern. Drug release study was customized by performing for 6 h in acidic environment to mimic gastroretention followed by basic environment akin to transit phase. Correlation between porous data from mercury and N(2) adsorption was probably studied for the first time. Observed regression analysis values for pore volume, surface area, and drug release indicated the influence of selected variables. Total release range in acidic medium was 12.77-24.57% for methanol, 8.79-15.26% for DCM, and final release of 69.45-92.23% for methanol, and 60.16-99.99% for DCM influenced by varying internal geometries was observed. Present form of drug delivery system devoid of any additives/excipients influencing drug release shows distinct behavior from other approaches/technologies in chronotherapy by (a) observing desired low drug release (8%) in acidic medium, (b) overcoming the limitations of process variables caused by multiple formulation steps and different characteristic polymers, (c) reducing time consumption due to single step process, and (d) extending as controlled/extended release.</p>10achronotherapy10afloating pulsatile drug delivery system10alow density porous carrier10apore data10asolvent polarity1 aSher, Praveen1 aIngavle, Ganesh, C.1 aPonrathnam, Surendra1 aPoddar, Pankaj1 aPawar, Atmaram, P.  uhttps://library.ncl.res.in/content/modulation-and-optimization-drug-release-uncoated-low-density-porous-carrier-based-0