01566nas a2200205   4500008004100000022001400041245009400055210006900149260007500218300001400293520078700307653002401094653003401118653002101152653001401173653002201187100001901209700001701228856011501245       2009                        eng d  a0936-521400aHydrolytic kinetic resolution as an emerging tool in the synthesis of bioactive molecules0 aHydrolytic kinetic resolution as an emerging tool in the synthes  aRUDIGERSTR 14, D-70469 STUTTGART, GERMANYbGEORG THIEME VERLAG KGcJUN  a1367-13823 a<p>A variety of racemic epoxides mainly derived from terminal olefins, such as aliphatic epoxides, multifuncitonalized epoxides and amine-substituted epoxides, have been successfully resolved into the enantiomerically pure epoxides and diols using Jacobsen's hydrolytic kinetic resolution (HKR) method. The chiral epoxides thus prepared were further elaborated by synthetic manipulation to provide a variety Of Compounds of biological interest. A general synthetic strategy for the construction Of S synlanti-1,3-polyol systems using iterative HKR has been developed, which was subsequently utilized in the synthesis of natural products with a broad range of biological activity. The protocol for the 1,3-polyols was also further extended to the synthesis of 1,3-amino alcohols.</p>10aBiological activity10aHydrolytic kinetic resolution10aNatural products10asynthesis10aterminal epoxides1 aKumar, Pradeep1 aGupta, Priti  uhttps://library.ncl.res.in/content/hydrolytic-kinetic-resolution-emerging-tool-synthesis-bioactive-molecules-0