01525nas a2200157   4500008004100000022001400041245014900055210006900204260010600273300001400379490000700393520079000400100002601190700001901216856013201235       2009                        eng d  a0040-402000aFacile approach to diverse range of 1,3-diaza-heterocycles: angular/linear selectivity paradigm and a remarkable intramolecular methyl migration0 aFacile approach to diverse range of 13diazaheterocycles angularl  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJUL  a5244-52500 v653 a<p>Starting from cyclic anhydrides and tert-butyl 2-aminobenzylcarbamate, simple and efficient synthesis of diverse range of kinetically controlled angular and thermodynamically controlled linear tricyclic and tetracyclic 1,3-diaza-heterocycles have been described via the intramolecular cyclizations of the corresponding imides/anilic acid esters. The effect of imide stability on the angular/linear product selectivity has also been described. The kinetically controlled angular products were successfully transformed to the corresponding thermodynamically controlled linear products by refluxing in methanol or methanol and acetic acid mixture. An interesting in situ 1,2-intramolecular methyl group migration has also been described. (C) 2009 Elsevier Ltd. All rights reserved.</p>1 aKshirsagar, Umesh, A.1 aArgade, N., P.  uhttps://library.ncl.res.in/content/facile-approach-diverse-range-13-diaza-heterocycles-angularlinear-selectivity-paradigm-and-0