01580nas a2200241   4500008004100000022001400041245008200055210006900137260010600206300001400312490000700326520070500333653001801038653002401056653001401080653001201094100002301106700002201129700002601151700002401177700002401201856011301225       2009                        eng d  a0960-894X00aDesign and synthesis of bile acid-based amino sterols as antimicrobial agents0 aDesign and synthesis of bile acidbased amino sterols as antimicr  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcSEP  a5411-54140 v193 a<p>New bile acid-based amino sterols were synthesized in good yields from C-3 beta-oxiranes as key intermediates. These derivatives were evaluated for their in vitro antimicrobial properties against human pathogens. These compounds showed better antibacterial activity as compared to antifungal activity. Compounds 21 and 22 showed comparable antibacterial activity to gentamicin against Staphylococcus aureus with IC(50) values of 5.14 and 4.46 mu g/mL. This is the first report for the synthesis of C-3 beta-oxiranes on the steroids having A/B cis ring junction and these oxiranes have been used for the synthesis of amino sterols 17, 18, 21, and 22. (C) 2009 Elsevier Ltd. All rights reserved.</p>10aAmino sterols10aAntibacterial agent10abile acid10aOxirane1 aAher, Nilkanth, G.1 aPore, Vandana, S.1 aMishra, Nripendra, N.1 aShukla, Praveen, K.1 aGonnade, Rajesh, G.  uhttps://library.ncl.res.in/content/design-and-synthesis-bile-acid-based-amino-sterols-antimicrobial-agents-0