01161nas a2200157   4500008004100000022001400041245012300055210006900178260011000247300001400357490000600371520044600377100002400823700002600847856013000873       2010                        eng d  a1477-052000aAmino/guanidino-functionalized N-(pyrrolidin-2-ethyl)glycine-based pet-PNA: design, synthesis and binding with DNA/RNA0 aAminoguanidinofunctionalized Npyrrolidin2ethylglycinebased petPN  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcJUN  a3742-37500 v83 a<p>The N-(pyrrolidin-2-ethyl) glycine-based PNA (pet-PNA) backbone, with 4-amino or 4-guanidino-functionalized pyrrolidine ring, confers constrained conformational flexibility on aegPNA. The oligomers bind to the target DNA and RNA sequences with increased sequence specificity and antiparallel versus parallel orientation selectivity. The easy post-synthetic guanidination gives very good access to the positively charged PNA oligomers.</p>1 aGokhale, Sachin, S.1 aKumar, Vaijayanti, A.  uhttps://library.ncl.res.in/content/aminoguanidino-functionalized-n-pyrrolidin-2-ethylglycine-based-pet-pna-design-synthesis-0