01597nas a2200205   4500008004100000022001400041245010300055210006900158260011000227300001200337490000700349520078500356100001801141700002301159700002101182700001901203700001701222700003001239856012201269       2010                        eng d  a1144-054600aCytotoxic and genotoxic assessment of glycolipid-reduced and -capped gold and silver nanoparticles0 aCytotoxic and genotoxic assessment of glycolipidreduced and capp  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcNOV  a294-3010 v343 a<p>A systematic cytotoxic and genotoxic evaluation of glycolipid-conjugated silver and gold nanoparticles is carried out. These glycolipid nanoparticle conjugates are obtained by exploiting the reductive capability of a class of glycolipids called sophorolipids that play the role of capping agent as well. Further, when tested for their cytotoxicity and genotoxicity on HepG2 cells, these nanoparticles are found to be cytocompatible up to 100 mu M metal concentrations. Of the two metallic systems investigated, gold nanoparticles are found to be more cytocompatible than the same concentrations of silver nanoparticles. Similarly, it is also demonstrated that at 100 mu M, silver nanoparticles cause more DNA damage compared to gold nanoparticles of similar concentrations.</p>1 aSingh, Sanjay1 aD'Britto, Virginia1 aPrabhune, Asmita1 aRamana, C., V.1 aDhawan, Alok1 aPrasad, Bhagavatula L. V.  uhttps://library.ncl.res.in/content/cytotoxic-and-genotoxic-assessment-glycolipid-reduced-and-capped-gold-and-silver-0