01791nas a2200157   4500008004100000022001400041245008500055210006900140260011500209300001200324490000600336520113600342100002001478700002301498856011201521       2010                        eng d  a1751-884900aRobustness of the drosophila segment polarity network to transient perturbations0 aRobustness of the drosophila segment polarity network to transie  aMICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLANDbINST ENGINEERING TECHNOLOGY-IETcMAR  a169-1760 v43 a<p>Continuous and Boolean models for the Drosophila segment polarity network have shown that the system is able to maintain the wild-type pattern when subjected to sustained changes in the interaction parameters and initial conditions. Embryo development is likely to occur under fluctuating environmental conditions. Here, a well-established Boolean model is used to explore the ability of the segment polarity network to resist transient changes. Paths along which alternate unviable states are reached, and hence critical nodes whose state changes lead the system away from the wild-type state, are identified. It is found that the system appears to be more sensitive to changes that involve activation of normally inactive nodes. Through a simulation of the heat shock response, it is shown how a localised perturbation in one parasegment is more deleterious than a global perturbation affecting all parasegments. The sequence of events involved in the recovery of the system from a global transient heat shock condition is identified. Finally, these results are discussed in terms of the robustness of the system response.</p>1 aSubramanian, K.1 aGadgil, Chetan, J.  uhttps://library.ncl.res.in/content/robustness-drosophila-segment-polarity-network-transient-perturbations-0