01528nas a2200169   4500008004100000022001400041245019800055210006900253260007100322300001400393490000700407520074700414100002401161700001801185700002601203856012901229       2010                        eng d  a0022-326300aProbing binding preferences of DNA and RNA: backbone chirality of thioacetamido-linked nucleic acids and iso-thioacetamido-linked nucleic acids to differentiate DNA versus RNA selective binding0 aProbing binding preferences of DNA and RNA backbone chirality of  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcNOV  a7431-74340 v753 a<p>Subtle differences in RNA and DNA duplex geometry could be sensed by the changed stereochemistry at 3 `-amino function in the 5-atom thioacetamido linker of thioacetamido-linked nucleic acids and iso-thioacetamido-linked nucleic acids modified oligomers. In contrast to the preferred N-type sugar conformations for either 3 `- ribo- or xylo amino nucleosides, predominant S-type sugar conformations were found in the dimers. Although the CD spectral differences for the dimer blocks were found to be identical for those found in phosphodiester linked ribo/xylo dimers, the 5-atom thioactamido linker could reverse the RNA binding selectivity to DNA binding selectivity by the change in configuration at the 3 `-amino-substituted sugar.</p>1 aGokhale, Sachin, S.1 aGogoi, Khirud1 aKumar, Vaijayanti, A.  uhttps://library.ncl.res.in/content/probing-binding-preferences-dna-and-rna-backbone-chirality-thioacetamido-linked-nucleic-0