01420nas a2200181   4500008004100000022001400041245013000055210006900185260011000254300001200364490000600376520064300382100001801025700002201043700002001065700002201085856013101107       2011                        eng d  a1759-995400aSynthesis of glycopolypeptides by the ring opening polymerization of O-glycosylated-alpha-amino acid N-carboxyanhydride (NCA)0 aSynthesis of glycopolypeptides by the ring opening polymerizatio  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcFEB  a805-8110 v23 a<p>The novel synthesis of O-glycosylated lysine-NCA from a stable glycosyl donor and a commercially available protected amino acid in very high yield is reported. These O-glycosylated lysine-NCA monomers underwent ring opening polymerization using simple primary amine initiators to form well defined, high molecular weight homoglycopolypeptides and diblock co-glycopolypeptides. The synthesis of azide labelled end functionalized glycopolypeptides and amphiphilic diblock copolypeptides is also reported. This methodology represents an easy and practical route to the synthesis of O-glycosylated polypeptides with 100% glycosylation.</p>1 aPati, Debasis1 aShaikh, Ashif, Y.1 aHotha, Srinivas1 aGupta, Sayam, Sen  uhttps://library.ncl.res.in/content/synthesis-glycopolypeptides-ring-opening-polymerization-o-glycosylated-alpha-amino-acid-n-0