01420nas a2200157   4500008004100000022001400041245009200055210006900147260011000216300001200326490000600338520074800344100002501092700002401117856012101141       2011                        eng d  a1477-052000aEnhanced stability of G-quadruplexes from conformationally constrained aep-PNA backbone0 aEnhanced stability of Gquadruplexes from conformationally constr  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcNOV  a725-7290 v93 a<p>Nucleic (DNA) acids having contiguous stretch of G sequence form quadruplex structure, which is very critical to control cell division. Recently the existence of G-quadruplex in RNA is also reported in presence of monovalent metal ion. PNA is a promising DNA analogue which binds strongly to DNA to form PNA: DNA duplex or PNA(2) : DNA triplex. PNA also forms quadruplexes such G-quadruplex and i-motif in G and C-rich sequences respectively. aep-PNA containing a prolyl ring is one of several PNA analogues that provide rigidity and chirality in backbone and has binding affinity to natural DNA which is higher than that of PNA. Here we examine the ability of aep-PNA-G to form a quadruplex by UV, CD and mass spectroscopic techniques.</p>1 aSharma, Nagendra, K.1 aGanesh, Krishna, N.  uhttps://library.ncl.res.in/content/enhanced-stability-g-quadruplexes-conformationally-constrained-aep-pna-backbone-0