01874nas a2200217   4500008004100000022001400041245011200055210006900167260011000236300001400346490000700360520102000367100001601387700002201403700002201425700001701447700002201464700001401486700002501500856013101525       2011                        eng d  a0306-001200aEmploying homoenolates generated by NHC catalysis in carbon-carbon bond-forming reactions: state of the art0 aEmploying homoenolates generated by NHC catalysis in carboncarbo  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcJUL  a5336-53460 v403 a<p>Homoenolate is a reactive intermediate that possesses an anionic or nucleophilic carbon beta to a carbonyl group or its synthetic equivalent. The recent discovery that homoenolates can be generated from alpha,beta-unsaturated aldehydes via N-Heterocyclic Carbene (NHC) catalysis has led to the development of a number of new reactions. A majority of such reactions include the use of carbon-based electrophiles, such as aldehydes, imines, enones, dienones etc. resulting in the formation of a variety of annulated as well as acyclic products. The easy availability of chiral NHCs has allowed the development of very efficient enantioselective variants of these reactions also. The tolerance showed by NHCs towards magnesium and titanium based Lewis acids has been exploited in the invention of cooperative catalytic processes. This tutorial review focuses on these and other types of homoenolate reactions reported recently, and in the process, updates the previous account published in 2008 in this journal.</p>1 aNair, Vijay1 aMenon, Rajeev, S.1 aBiju, Akkattu, T.1 aSinu, C., R.1 aPaul, Rony, Rajan1 aJose, Anu1 aSreekumar, Vellalath  uhttps://library.ncl.res.in/content/employing-homoenolates-generated-nhc-catalysis-carbon-carbon-bond-forming-reactions-state-0