01436nas a2200205   4500008004100000022001400041245012200055210006900177260010600246300001400352490000700366520054900373653008500922653000901007653001601016100002301032700002201055700002601077856012701103       2011                        eng d  a0040-402000aRobust synthesis of enantiopure cyclohexenyl analogues of 2/3-deoxyribose sugars as carbocyclic nucleoside precursors0 aRobust synthesis of enantiopure cyclohexenyl analogues of 23deox  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcAUG  a5744-57490 v673 a<p>An expedient synthesis of 2-deoxy (10) and 3-deoxy (11) cyclohexenyl analogues of 2-deoxy and 3-deoxy-D-ribose sugar from commercially available starting materials is reported. Highly efficient enzymatic resolution of the key compound 10 is described using lipase under hydrolytic conditions. The robust methodology applied here will be useful to synthesize cyclohexenyl nucleosides, which possess potent antiviral activity and are capable of gene silencing via RNAi or antisense applications. (C) 2011 Elsevier Ltd. All rights reserved.</p>10aCarbocyclic mimics of 2-deoxy-D-ribose and 3-deoxy-D-ribose Enzymatic resolution10aCeNA10aDA reaction1 aVarada, Manojkumar1 aKotikam, Venubabu1 aKumar, Vaijayanti, A.  uhttps://library.ncl.res.in/content/robust-synthesis-enantiopure-cyclohexenyl-analogues-23-deoxyribose-sugars-carbocyclic-0