01933nas a2200193   4500008004100000022001400041245010500055210006900160260007100229300001600300490000800316520117500324100001901499700002001518700002301538700003001561700002201591856012601613       2011                        eng d  a1932-744700aFunctionalization of SBA-15 mesoporous materials using ``thiol-ene click'' michael addition reaction0 aFunctionalization of SBA15 mesoporous materials using thiolene c  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcSEP  a17774-177810 v1153 a<p>Methacrylate-labeled SBA-15 has been successfully synthesized from calcined SBA-15 and commercially available 3-trichlorosilyl propylmethacrylate. This material undergoes efficient thiol-ene ``click reaction'' with a variety of both thiol and disulfide-containing substrates in aqueous and organic media. The products were thoroughly characterized by a variety of analytical techniques including multinuclear (C-13, Si-29) solid-state NMR, TG-DTA, and nitrogen adsorption desorption studies. Disulfide-containing substrates in which the TCEP-mediated reduction of the disulfide bond and its subsequent addition to the methacrylate group anchored in SBA-15 in one-pot were used to synthesize a silica-protein hybrid material composed of biotin-labeled SBA-15 and streptavidin. Electrochemically active material was synthesized from the reaction of ferrocene-containing thiol and the methacrylate-labeled SBA-15. The ease of synthesis for the methacrylate-labeled SBA-15 material together with its ability to undergo efficient chemoselective thiol-ene reaction would make it a very attractive platform for the development of covalently anchored enzymes and sensors.</p>1 aKumari, Sushma1 aMalvi, Bharmana1 aGanai, Anal, Kumar1 aPillai, Vijayamohanan, K.1 aGupta, Sayam, Sen  uhttps://library.ncl.res.in/content/functionalization-sba-15-mesoporous-materials-using-thiol-ene-click-michael-addition-0