02074nas a2200217   4500008004100000022001400041245010100055210006900156260007600225300001200301490000800313520126200321653001401583653001801597653001801615653001501633653002701648100002601675700002401701856013101725       2011                        eng d  a0021-899500aSynthesis and characterization of bile acid-based poly beta amino esters for paclitaxel delivery0 aSynthesis and characterization of bile acidbased poly beta amino  aCOMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USAbWILEY-BLACKWELLcOCT  a220-2320 v1223 a<p>New biodegradable poly beta amino esters were synthesized by the polymerization of Deoxycholic acid (DOCA) in all the structural planes by 1, 4 addition of Trimethylene dipiperidine (TMDP) to diacrylates of Deoxycholyl glycol, Methyl deoxycholate and Trimethylolpropane deoxycholate esters. H-1-NMR, C-13-NMR and IR studies confirmed presence of amine and Deoxycholyl units in polymers. XRD and TGA studies indicated that all the polymers were amorphous and thermostable up to 300 degrees C. DSC studies revealed glass transition temperature (T-g) in the range 70-80 degrees C. All the polymers degraded very slowly in the buffers of pH 1.1, 7.4 and 10 because of the hydrophobic nature of Deoxycholate units. These polymers also exhibited pH sensitivity due to the incorporation of amines along with Deoxycholate units in the backbone. P-Nitroaniline (PNA) release followed anomalous release kinetics. Paclitaxel (PTX) loaded nanospheres prepared from these polymers were spherical and uniform in the size range 75-250 nm and 0.4-1 mu depending upon the method of preparation. PTX loading was in the range 60-90%, while release (up to 20-60%) was sustained over a period of 100 h. (c) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 122: 220-232, 2011</p>10abile acid10abiodegradable10aNanoparticles10aPaclitaxel10apoly beta amino esters1 aGangwal, Jitendra, J.1 aKulkarni, Mohan, G.  uhttps://library.ncl.res.in/content/synthesis-and-characterization-bile-acid-based-poly-beta-amino-esters-paclitaxel-delivery-0