02017nas a2200229   4500008004100000022001400041245013900055210006900194260011000263300001400373490000600387520110100393100002301494700002001517700002701537700001601564700001701580700002201597700002001619700001801639856013001657       2011                        eng d  a2040-250300aHierarchical mesoporous bio-polymer/silica composites co-templated by trimethyl chitosan and a surfactant for controlled drug delivery0 aHierarchical mesoporous biopolymersilica composites cotemplated   aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcDEC  a1162-11660 v23 a<p>In this communication, we report the facile synthesis of hierarchical mesoporous bio-polymer/silica composite materials with bimodal mesopores using a dual-template of the cationic N,N,N-trimethyl chitosan (TMCs) and the anionic sodium dodecyl sulfate (SDS) via one-step synthetic strategy. Tetraethoxysilane (TEOS) was used as a silica source. The nitrogen adsorption/desorption measurements and transmission electron microscopy analysis showed the hierarchical structure of the mesoporous bio-polymer/silica composites with bimodal mesopores having an average pore size of 5-7 nm with the visible voids between the silica nanoparticles, which allow the mesoporous bio-polymer/silica composites to encapsulate a large number of guest drug molecules, Ibuprofen (IBU) or 5-fluorouracil (5-FU), due to their high surface area and pore volume. In addition, the mesoporous chitosan-silica composites also had a long term biocompatibility for the target release of the drug molecules to the CEM cells, MCF cells, etc. as well as a pH sensitive controlled release behavior of the drug molecules.</p>1 aRana, Vijay, Kumar1 aPark, Sung, Soo1 aParambadath, Surendran1 aKim, Mi, Ju1 aKim, Sun-Hee1 aMishra, Satyendra1 aSingh, Raj, Pal1 aHa, Chang-Sik  uhttps://library.ncl.res.in/content/hierarchical-mesoporous-bio-polymersilica-composites-co-templated-trimethyl-chitosan-and-0