01722nas a2200169   4500008004100000022001400041245011700055210006900172260011000241300001400351490000700365520098000372100001701352700003301369700002201402856012801424       2012                        eng d  a0306-001200aRecent advances in transition-metal-free carbon-carbon and carbon-heteroatom bond-forming reactions using arynes0 aRecent advances in transitionmetalfree carboncarbon and carbonhe  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcJAN  a3140-31520 v413 a<p>This tutorial review is aimed at highlighting recent developments in transition-metal-free carbon-carbon and carbon-heteroatom bond-forming reactions utilizing a versatile class of reactive intermediates, viz., arynes, which hold the potential for numerous applications in organic synthesis. Key to the success of the resurgence of interest in the rich chemistry of arynes is primarily the mild condition for their generation by the fluoride-induced 1,2-elimination of 2-(trimethylsilyl)aryl triflates. Consequently, arynes have been employed for the construction of multisubstituted arenes with structural diversity and complexity. The versatile transition-metal-free applications of arynes include cycloaddition reactions, insertion reactions and multicomponent reactions. In addition, arynes have found applications in natural product synthesis. Herein, we present a concise account of the major developments that occurred in this field during the past eight years.</p>1 aBhunia, Anup1 aYetra, Santhivardhana, Reddy1 aBiju, Akkattu, T.  uhttps://library.ncl.res.in/content/recent-advances-transition-metal-free-carbon-carbon-and-carbon-heteroatom-bond-forming-0