01896nas a2200157   4500008004100000022001400041245008500055210006900140260011800209300001200327490000800339520123600347100001701583700001901600856011901619       2012                        eng d  a1350-087200aNitrate reduction pathways in mycobacteria and their implications during latency0 aNitrate reduction pathways in mycobacteria and their implication  aMARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG, BERKS, ENGLANDbSOC GENERAL MICROBIOLOGYcFEB  a301-3070 v1583 a<p>Mycobacterial persistence has gained a lot of attention with respect to developing novel antitubercular drugs, which could drastically reduce the duration of tuberculosis (TB) therapy. A better understanding of the physiology of Mycobacterium tuberculosis, and of the metabolic state of the bacillus during the latent period, is a primary need in finding drug targets against persistent TB. Recent biochemical and genetic studies of nitrate reduction in mycobacteria have revealed the roles of distinct proteins and enzymes involved in the pathway. The differential degree of nitrate reduction among pathogenic and non-pathogenic mycobacterial species, and its regulation during oxygen and nutrient limitation, suggest a link between nitrate reduction pathways and latency. The respiratory and assimilatory reduction of nitrate in mycobacteria may be interconnected to facilitate rapid adaptation to changing oxygen and/or nitrogen conditions, increasing metabolic flexibility for survival in the hostile host environment. This review summarizes the nitrate metabolic pathways operative in mycobacteria to provide an insight into the mechanisms that M. tuberculosis has evolved to adapt successfully to the host environment.</p>1 aKhan, Arshad1 aSarkar, Dhiman  uhttps://library.ncl.res.in/content/nitrate-reduction-pathways-mycobacteria-and-their-implications-during-latency-0