01358nas a2200217   4500008004100000022001400041245010700055210006900162260011000231300001200341490000600353520049100359100002200850700002400872700002400896700002400920700002600944700001800970700002400988856012801012       2012                        eng d  a2040-250300aSynthesis and antifungal activity of 1,5-disubstituted-1,2,3-triazole containing fluconazole analogues0 aSynthesis and antifungal activity of 15disubstituted123triazole   aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcAPR  a484-4880 v33 a<p>Fluconazole based novel mimics containing 1,5-disubstituted 1,2,3-triazoles were synthesized by using Ru catalysed 1,3 dipolar cycloaddition. All the newly synthesized compounds and pure enantiomers were more potent than fluconazole against Candida albicans. Docking of 9A and 9B showed different conformation in the active site of Cyp51 of Candida albicans. The more active compounds 2 and 2A did not exhibit any toxicity up to 3.12 mu g mL(-1) against mammalian cell line L929.</p>1 aPore, Vandana, S.1 aJagtap, Manisha, A.1 aAgalave, Sandip, G.1 aPandey, Atindra, K.1 aSiddiqi, Mohammad, I.1 aKumar, Vikash1 aShukla, Praveen, K.  uhttps://library.ncl.res.in/content/synthesis-and-antifungal-activity-15-disubstituted-123-triazole-containing-fluconazole-0