01250nas a2200205   4500008004100000022001400041245009300055210006900148260007100217300001400288490000800302520048800310100002100798700002400819700001100843700002400854700001900878700002600897856012100923       2012                        eng d  a0002-786300aHighly efficient (R-X-R)-type carbamates as molecular transporters for cellular delivery0 aHighly efficient RXRtype carbamates as molecular transporters fo  a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcMAY  a7196-71990 v1343 a<p>The (R-X-R) motif-containing arginine-rich peptides are among the most effective cell-penetrating peptides. The replacement of amide linkages in the (R-X-R) motif by carbamate linkages as in (r-ahx-r)(4) or (r-ahx-r-r-apr-r)(2) increases the efficacy of such oligomers several-fold. Internalization of these oligomers in mammalian cell lines occurs by an energy-independent process. These oligomers show efficient delivery of biologically active plasmid DNA into CHO-K1 cells.</p>1 aPatil, Kiran, M.1 aNaik, Rangeetha, J.1 aRajpal1 aFernandes, Moneesha1 aGanguli, Munia1 aKumar, Vaijayanti, A.  uhttps://library.ncl.res.in/content/highly-efficient-r-x-r-type-carbamates-molecular-transporters-cellular-delivery-0