01074nas a2200157 4500008004100000022001400041245006900055210006900124260010600193300001200299490000700311520045600318100002000774700001900794856010300813 2012 eng d a0957-416600aFormal synthesis of tetrahydrolipstatin and tetrahydroesterastin0 aFormal synthesis of tetrahydrolipstatin and tetrahydroesterastin aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJUN a884-8900 v233 a

A versatile and efficient approach to (3.5,5R)-methyl 3-(benzyloxy)-5-(methoxymethoxy)hexadecanoate, a key chiral building block and a common polyol fragment of the anti-tumor and anti-obesity agents tetrahydrolipstatin 3 and tetrahydroesterastin 4 using both hydrolytic kinetic resolution (HKR) and proline catalyzed sequential alpha-aminoxylation, followed by HWE-olefination reaction is described. (c) 2012 Elsevier Ltd. All rights reserved.

1 aTripathi, Divya1 aKumar, Pradeep uhttps://library.ncl.res.in/content/formal-synthesis-tetrahydrolipstatin-and-tetrahydroesterastin-0